Family name Desanctis (Desanctis 
) , around the world, is a rare last name. The cognomen Desanctis is characteristic of the United States, where it is a rare surname, Italy, and Canada, where it is a very rare surname. In absolute terms, it is commonest in the United States, Italy, and France.
| VARIANT | COUNTRY |
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| Desanctis | United Kingdom, Italy, United States, Canada, France |
| luigi desanctis Italian theologian, IT (b. 1808) |
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adriana desanctis figure skater, CA (b. 1988) |
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| gerardine desanctis American organizational theorist (b. 1954) |
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| ellen desanctis American businessperson and board member, director at Plains All American Pipeline |
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