Surname Sharpless (Sharpless 
) , across the world, is quite a rare last name. The last name Sharpless is characteristic of the United States, where it is a rare surname, the United Kingdom, and Australia.
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| Sharpless | Australia, Canada, United States, New Zealand, United Kingdom |
| mira sharpless townsend Quaker activist and reformer, US (b. 1798) |
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| abigail sharpless (1807-1837) (b. 1807) |
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| isaac sharpless American historian, US (b. 1848) |
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ada mae sharpless American sculptor, US (b. 1899) |
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karl barry sharpless American chemist and Nobel Laureate (born 1941), US (b. 1941) |
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| edith forsythe sharpless (b. 1883) |
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norman sharpless American cancer researcher, US (b. 1966) |
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| nansie s. sharpless American biochemist and deaf advocate, US (b. 1932) |
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| don sharpless sound engineer (1933-2017), US (b. 1933) |
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| mattie r. sharpless American diplomat (b. 1943) |
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| john sharpless American politician, US (b. 1945) |
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| christopher sharpless United States Virgin Islands bobsledder, US (b. 1945) |
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| rebecca sharpless (b. 1958) |
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| carole sharpless American triathlete, US (b. 1971) |
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| toni sharpless Pennsylvania disappearance case, US (b. 1979) |
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