Last name Santayana (Santayana 
) , across the world, is quite a rare surname. The family name Santayana is habitual in Peru, where it is a rare surname, Uruguay, and Philippines. Not in comparison with a country's population, this name is the most popular in Philippines, Peru, and the United States. Very seldom, Santayana is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Santayana | Indonesia, Philippines, Spain, Peru, United States |
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george santayana Spanish-American philosopher, ES (b. 1863) |
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mauro santayana Brazilian journalist, BR (b. 1932) |
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josé ignacio pardo de santayana Spanish naturalist, ES (b. 1945) |
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| manuel pardo de santayana botanist |
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| santayana kiemas Indonesian political candidate, ID |
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| agustín ruiz de santayana ES |
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Mr, Ciro, Kary, Kurt, Rama, Rose, Rita, Ryan, Dora, Greg, Gian, Gina, Glen, Lino, Luis, Jose, Juan, Thea, Tess, Nara, Nida, Nora, Carl, Anna, Alba, Alex, Ms, May, Max, Sol, Ana, Ann, Anh, Ave, Roy, Rio, Noel, Lou, Jay, Jen, Jim, J-R, Ema, Ian, Marc, Mary, Mark, Sara, Luz, and Nery