Last name Osornio (Osornio 
) , globally, is a common surname. The cognomen Osornio is habitual in Mexico, where it is quite a common surname, the United States, where it is a rare surname, and Canada.
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| Osornio | Spain, Mexico, United States, Argentina, Canada |
| francisco lópez osornio Spanish military officer, ES (b. 1600) |
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clemente lópez de osornio South American military captain and rancher, AR (b. 1720) |
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| ramón lópez de osornio Argentine landowner and military officer, AR (b. 1685) |
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agustina lópez de osornio (1769-1845), AR (b. 1769) |
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saturnino osornio Mexican politician (1896-1976), MX (b. 1896) |
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| josé gutiérrez osornio (b. 1910) |
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| arturo osornio Mexican politician, MX (b. 1953) |
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| josé sifuentes osornio (b. 1953) |
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| erick osornio Mexican taekwondo practitioner, MX (b. 1983) |
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