Family name Dufrene (Dufrene 
) , globally, is quite a rare last name. The cognomen Dufrene is characteristic of France, where it is quite a rare surname, Haiti, where it is a rare surname, and the United States. Very seldom, Dufrene is the forename as well as the last name.
| ronil dufrene American soccer player, US (b. 1962) |
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| mike dufrene college basketball player (1984–1987) George Mason |
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| vincent dufrene FR (b. 1975) |
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| luc dufrene FR (b. 1981) |
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| prescillia dufrene French association football player, FR (b. 1995) |
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