Family name De Michele (De Michele 
) , all over the world, is quite a rare last name. The cognomen De Michele is habitual in Italy, where it is quite a rare surname, Luxembourg, and Argentina, where it is a rare surname. Measured by absolute frequency, the name is most common in Italy, Argentina, and Afghanistan. Very seldom, De Michele is the forename as well as the last name.
| VARIANT | COUNTRY |
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| De Michele | France, Democratic Republic of the Congo, Argentina, Afghanistan, Italy |
Michaelson, and מייקלסון
| ettore de michele Italian association football player and association football referee (1890-1991), IT (b. 1890) |
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| luigi de michele Italian politician, IT (b. 1903) |
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| gerardo de michele Italian physician and politician, IT (b. 1917) |
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| vincenzo de michele Italian politician (1920), IT (b. 1920) |
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| vincenzo de michele former curator of the Natural History Museum, Milan (b. 1936) |
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| graziella de michele French singer-songwriter, FR (b. 1956) |
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| stefania de michele Italian basketball player (1971-), IT (b. 1971) |
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| giovanna de michele researcher |
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| elisa de michele Italian hematologist, IT |
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| cristiano de michele researcher |
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| francesco de michele researcher |
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| giuseppe de michele |
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