Family name Spagnolo (Spagnolo 
, Espaignol , Спаньоло) , around the globe, is a common cognomen. The family name Spagnolo is characteristic of Italy, where it is quite a common surname, Argentina, where it is quite a rare surname, and Luxembourg. In absolute terms, the name is most common in Italy, Argentina, and the United States. Very seldom, Spagnolo is the forename as well as the last name.
| don antonio spagnolo Italian paleographer, IT (b. 1863) |
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| kathleen mary spagnolo American artist (b. 1919) |
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mariano spagnolo Argentinian singer, AR (b. 1974) |
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| duilio spagnolo Italian boxer, IT (b. 1927) |
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| robert spagnolo rugby union player (1929-2009), FR (b. 1929) |
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| francesco spagnolo IT (b. 1920) |
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| paolo spagnolo Italian pianist (1930-2012), IT (b. 1930) |
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| corrado spagnolo IT (b. 1922) |
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| franca tonello spagnolo Barbeano 1934 - 1992 (b. 1934) |
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| nelson spagnolo Uruguayan writer, UY (b. 1939) |
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eli spagnolo CH |
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| sergio spagnolo Italian mathematician (1941-), IT (b. 1941) |
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| renato spagnolo Italian physicist (1946-2021), IT (b. 1946) |
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| giampietro spagnolo Italian association football player, IT (b. 1949) |
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| massimo spagnolo Italian economist, IT (b. 1951) |
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