Cognomen Santomé (Santomé 
) , throughout the world, is a very rare family name. The family name Santomé is characteristic of Uruguay, where it is a rare surname, Spain, and Argentina, where it is a very rare surname. Much less frequently, Santomé is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Santomé | Uruguay, Mexico, Spain, Argentina, Colombia |
| jesús santomé Spanish association football player, ES (b. 1955) |
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| juan carlos santomé ES (b. 1969) |
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| mónica valderrama santomé ES (b. 1974) |
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| antonio menduiña santomé ES (b. 1976) |
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| cecilia fernández santomé ES (b. 1984) |
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Ana, Rubén, Daniel, Gloria, Lucía, Javier, Jesús, Judith, Tomás, Emilio, Victor, Martín, Mónica, Sérgio, Alberto, Alfonso, Andrés, Analía, Antonio, Adrián, Cynthia, Roberto, Carlos, Adolfo, Sofía, Silvia, Eva, Alex, Lara, Jose, Juan, Iria, Saúl, Suyai, Carla, Brais, Ricardo, Pablo, Diana, Laura, José, Jorge, Tania, Irene, Oscar, María, Manuel, Miguel, David, and Gabriel