Last name Opdyke (Opdyke 
) , around the world, is a rare cognomen. The surname Opdyke is characteristic of the United States, where it is a rare surname, Australia, where it is a very rare surname, and Canada.
| VARIANT | COUNTRY |
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| Opdyke | Australia, Thailand, United States, Canada, France |
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george opdyke American politician, US (b. 1805) |
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| amelia opdyke jones American cartoonist (1913-1993), US (b. 1913) |
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| irene gut opdyke Polish nurse, PL (b. 1922) |
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| neil d. opdyke geologist, US (b. 1933) |
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| william opdyke American computer scientist and enterprise architect, US (b. 1958) |
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| david opdyke American artist, born 1969, US (b. 1969) |
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