Cognomen O'Byrne (O'Byrne 
) , globally, is quite a rare surname. The last name O'Byrne is characteristic of Ireland, where it is quite a common surname, Isle of Man, where it is quite a rare surname, and Australia. Not in comparison with a country's population, this name is the most popular in Ireland, Australia, and the United Kingdom.
| VARIANT | COUNTRY |
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| O'Byrne | United Kingdom, Ireland, Australia, Canada, United States |
| brian o'byrne Peerage person ID=362275 (b. 1593) |
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| robert o'byrne (1789-1861) (b. 1789) |
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thomas francis o'byrne Timber worker, trade unionist, politician (1871-1952), NZ (b. 1871) |
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| william richard o'byrne Irish biographer (1823-1896), GB (b. 1823) |
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eleanor o'byrne American Catholic Nun, US (b. 1896) |
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| cathal o'byrne Irish writer, IE (b. 1867) |
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| patrick o'byrne Irish politician, IE (b. 1870) |
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| john o'byrne Irish barrister, Attorney General and judge, IE (b. 1884) |
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| john joseph gabriel o'byrne FR (b. 1878) |
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fergus o'byrne Irish-Canadian musician, CA (b. 1947) |
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| harold i. o'byrne entomologist (1898-1951) (b. 1898) |
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| william o'byrne cricketer (1908-1951), GB (b. 1908) |
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| patrick o'byrne French military officer (1909-1977), FR (b. 1909) |
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| justin o'byrne Australian politician (1912-1993), AU (b. 1912) |
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david o'byrne Australian politician and trade unionist, AU (b. 1969) |
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