Last name Macisaac (Macisaac 
) , in all the world, is quite a rare surname. The last name Macisaac is habitual in Canada, where it is quite a rare surname, New Zealand, and Australia, where it is a rare surname. In absolute terms, it most frequently occurs in Canada, the United States, and the United Kingdom.
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| Macisaac | Australia, New Zealand, United Kingdom, United States, Canada |
| peter a. macisaac Canadian politician, CA (b. 1878) |
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| john a. macisaac Canadian politician, CA (b. 1883) |
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| fred macisaac US (b. 1886) |
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| angus macisaac Australian footballer (1900-1944), AU (b. 1900) |
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| dugald macisaac Scottish chess player, GB (b. 1901) |
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| alexander macisaac Canadian politician, CA (b. 1907) |
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steve macisaac Canadian comic creator, CA (b. 1969) |
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ashley macisaac Canadian musician, CA (b. 1975) |
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martha macisaac Canadian actress, CA (b. 1984) |
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| john macisaac British sprinter, GB (b. 1937) |
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| jack macisaac Canadian politician, CA (b. 1939) |
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| angus macisaac Canadian politician, CA (b. 1943) |
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| greg macisaac Canadian politician, CA (b. 1945) |
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maya macisaac-jones Canadian cross-country skier, CA (b. 1995) |
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| dave macisaac Canadian musician, CA (b. 1955) |
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