Surname Knöpfli (Knöpfli 
) , across the world, is a very rare last name. The family name Knöpfli is characteristic of Switzerland, where it is a rare surname, Germany, where it is a very rare surname, and the United States, where it is an extremely rare surname. Much less frequently, Knöpfli is the forename as well as the last name.
| claudio knöpfli CH (b. 1954) |
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| sonja knöpfli Swiss athletics competitor, CH (b. 1977) |
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