Surname Isaacson (Isaacson 
, איזקסון ) , in the entire world, is quite a common family name. The family name Isaacson is characteristic of Israel, where it is quite a rare surname, the United States, and Australia. In absolute terms, it is commonest in the United States, the United Kingdom, and Canada.
| VARIANT | COUNTRY |
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| Isaacson | United Kingdom, Canada, Israel, Australia, United States |
| איזקסון | Israel |
| henry isaacson English chronologist and biographer (b. 1581) |
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| james isaacson English Member of Parliament (1660-1724) (b. 1660) |
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| ann isaacson (1773-1840) (b. 1773) |
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| stephen isaacson English writer (1798–1849) (b. 1798) |
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| john frederick isaacson (1802-1886) (b. 1802) |
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| frederick wootton isaacson British politician and businessman (b. 1835) |
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| john frederick isaacson (born 1842) (b. 1842) |
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| henry wyhead isaacson (born 1844) (b. 1844) |
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| thomas francis isaacson (born 1844) (b. 1844) |
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| arthur isaacson (1846-1927) (b. 1846) |
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| lydia isaacson Peerage person ID=642422 (b. 1847) |
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| robert fraser isaacson (born 1848) (b. 1848) |
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| mary rebecca isaacson (born 1850) (b. 1850) |
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| frederick j. f. w. isaacson (born 1858) (b. 1858) |
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| joseph jacob isaacson Dutch painter (1859-1942), NL (b. 1859) |
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