Surname Difrancesco (Difrancesco 
) , in the entire world, is quite a rare family name. The cognomen Difrancesco is characteristic of Italy, where it is a rare surname, Canada, and the United States.
| VARIANT | COUNTRY |
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| Difrancesco | United Kingdom, Italy, Australia, United States, Canada |
Di Francesco, and Дифранцесцо
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donald difrancesco American politician, US (b. 1944) |
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david difrancesco American photoscientist, inventor, cinematographer, and photographer (b. 1949) |
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| dario difrancesco Italian cardiac physiologist, IT (b. 1948) |
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| jacopo c. difrancesco researcher (b. 1978) |
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| loretta difrancesco researcher |
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| mattia lorenzo difrancesco researcher |
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| sonia difrancesco researcher (ORCID 0000-0001-7254-3686) |
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| orazio difrancesco researcher |
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| mark difrancesco researcher |
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| robin difrancesco researcher (ORCID 0000-0001-7418-2546) |
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