Family name Destefano (Destefano 
, De Stefano ) , throughout the world, is a common cognomen. The last name Destefano is characteristic of Italy, where it is quite a common surname, Argentina, where it is quite a rare surname, and the United States.
| fred destefano American football player (1900-1974), US (b. 1900) |
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john destefano, jr. American mayor, US (b. 1955) |
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| sam destefano American mobster, US (b. 1909) |
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anthony destefano American spiritual author, US (b. 1965) |
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| mario anthony destefano American mobster (b. 1915) |
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john destefano American political advisor, US (b. 1978) |
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chris destefano American singer/songwriter, record producer and multi instrumentalist, US |
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| joe destefano American politician, US (b. 1960) |
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| robert destefano American chiropractor, US (b. 1962) |
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| dina destefano US professional wrestling manager, US (b. 1963) |
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| mike destefano American stand-up comedian (1966-2011), US (b. 1966) |
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| stephen destefano (b. 1956) |
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| stephen destefano American comics artist, US (b. 1966) |
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| matthew r destefano researcher |
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| alisa anne destefano Ph.D. Dartmouth College 1992 |
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