Surname Desimone (Desimone 
, Десимоне 
) , all around the world, is a common family name. The last name Desimone is habitual in Cayman Islands, where it is quite a common surname, Argentina, where it is quite a rare surname, and the United States. In absolute terms, it most frequently occurs in the United States, Argentina, and Italy.
| VARIANT | COUNTRY |
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| Desimone | Canada, Kenya, Argentina, Italy, United States |
| Десимоне | Russia |
| giuseppe desimone Italian politician, IT (b. 1811) |
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frank desimone American mobster, US (b. 1909) |
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| rosario desimone head of an Italian crime family, US (b. 1873) |
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antonio desimone Italian mathematician (1962-), IT (b. 1962) |
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joseph desimone American chemist, inventor and entrepreneur born in May 16, 1964, US (b. 1964) |
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edward desimone iii American senior staff of Cantor Fitzgerald, victim of the September 11 attacks, US (b. 1964) |
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| vincent desimone American police detective (b. 1918) |
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| louis a. desimone Catholic bishop (1922-2018), US (b. 1922) |
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| herbert f. desimone American politician (1929-2013), US (b. 1929) |
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phil desimone American ice hockey player, US (b. 1987) |
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| tom desimone American director, US (b. 1939) |
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| bob desimone American actor, US (b. 1945) |
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| thomas desimone American mobster, US (b. 1950) |
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| russell j. desimone (b. 1944) |
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| john desimone American politician, US (b. 1960) |
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