Family name Desantiago (Desantiago 
) , throughout the world, is quite a rare surname. The family name Desantiago is habitual in Venezuela, where it is quite a rare surname, Puerto Rico, and the United States, where it is a rare surname. In absolute terms, the name is most common in the United States, Venezuela, and Mexico. Very seldom, Desantiago is the forename as well as the last name.
| VARIANT | COUNTRY |
|---|---|
| Desantiago | Mexico, United States, Puerto Rico, Canada, Venezuela |