Surname De Francesco (De Francesco 
) , worldwide, is quite a common family name. The last name De Francesco is characteristic of Italy, where it is quite a common surname, Argentina, where it is quite a rare surname, and Australia, where it is a rare surname. In absolute terms, it is the most numerous in Italy, Argentina, and the United States.
| VARIANT | COUNTRY |
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| De Francesco | Canada, Argentina, France, United States, Italy |
| beniamino de francesco Italian painter (1815-1869), IT (b. 1815) |
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| domenico de francesco Italian mathematician (1869-after 1903), IT (b. 1869) |
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emanuele de francesco Italian police officer and civil servant, IT (b. 1921) |
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| nicola de francesco Italian painter and sculptor (1898-1991), IT (b. 1898) |
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| grete de francesco AT (b. 1893) |
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| renato de francesco IT (b. 1900) |
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stefania de francesco Italian actress, IT (b. 1973) |
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| marcella de francesco IT (b. 1920) |
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| giovannangelo de francesco Italian jurist (1950-), IT (b. 1950) |
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| antonino de francesco Italian historian and university professor (1954-), IT (b. 1954) |
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| roberto de francesco Italian actor, IT (b. 1964) |
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| alessandro de francesco Italian writer, IT (b. 1969) |
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| klaus de francesco chess player (b. 1969) |
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| francesco de francesco Italian footballer, IT (b. 1977) |
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| francesco de francesco Italian voice actor, IT (b. 1978) |
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