Cognomen Sapiano (Sapiano 
) , globally, is a rare family name. The family name Sapiano is habitual in Malta, where it is quite a common surname, Bulgaria, where it is a rare surname, and Canada. In absolute terms, it is the most numerous in Malta, the United Kingdom, and the United States. Very seldom, Sapiano is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Sapiano | Canada, Malta, United Kingdom, United States, Nigeria |
| michelangelo sapiano Maltese clock maker, MT (b. 1826) |
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| joseph sapiano 20th century Maltese philosopher, MT (b. 1911) |
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edward sapiano Canadian lawyer, CA |
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| mathew r p sapiano researcher |
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| paul sapiano |
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Mr, Simon, Steve, Carol, Caine, Keith, Kevin, Kymea, Peter, Rhona, Dario, David, Diane, Georg, Gemma, Grace, Gitta, Laura, Lewis, Linda, Sarah, Maria, Inez, Emma, Ms, Ann, Kim, Mary, Mark, Matt, Alex, Bert, Kurt, Luigi, Paul, Rita, Ryan, Lucy, Luke, John, Jean, Tara, Thea, Tony, Rick, and Jason