Last name Safieddine (Safieddine 
) , in the world, is quite a rare surname. The cognomen Safieddine is characteristic of Lebanon, where it is quite a common surname, Zambia, where it is quite a rare surname, and Sierra Leone. Measured by absolute frequency, it is the most numerous in Lebanon, Zambia, and Morocco. Very seldom, Safieddine is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Safieddine | Zambia, Morocco, Egypt, Senegal, Lebanon |
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francois safieddine American poker player, US |
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joseph safieddine French cartoonist, FR (b. 1986) |
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| faten safieddine Lebanese artist, photographer and writer, LB (b. 1954) |
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| sayyed hashem safieddine (b. 1964) |
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| adham safieddine researcher |
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| saaid safieddine researcher |
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Mr, Amer, Adel, Adam, Adil, Atef, Aziz, Kari, Rami, Rana, Amin, Rafa, Rola, Reda, Reem, Rita, Rima, Dina, Dima, Doha, Lana, Raef, Amal, Arwa, Anne, Ms, May, Sam, Ali, Ana, Aya, Jad, Eng, Maya, Maha, Majd, Mona, Moha, Mike, Mimi, Sara, Said, Sadu, Alia, Alaa, Alya, Leen, and Lina