Last name Mkhatshwa (Mkhatshwa 
) , across the world, is a common cognomen. The family name Mkhatshwa is habitual in Eswatini, where it is a common surname, South Africa, where it is quite a common surname, and the United Kingdom, where it is a very rare surname. Not in comparison with a country's population, it is the most numerous in South Africa, Eswatini, and the United States. Very seldom, Mkhatshwa is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Mkhatshwa | Eswatini, Australia, United States, United Kingdom, South Africa |
| smangaliso mkhatshwa South African priest, ZA (b. 1939) |
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| vusi mkhatshwa South African politician (b. 1979) |
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| nompendulo thobile mkhatshwa member of the National Assembly of South Africa |
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| thembinkosi peter sydney mkhatshwa Ph.D. Syracuse University 2016 |
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| nompendulo mkhatshwa South African politician (b. 1993) |
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