Family name Letsie (Letsie 
, מלך) , globally, is a common surname. The last name Letsie is characteristic of Sub-Saharan Africa, particularly Lesotho, where it is a widespread surname, Botswana, where it is quite a rare surname, and South Africa. Much less frequently, Letsie is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Letsie | United Kingdom, Botswana, South Africa, Democratic Republic of the Congo, Lesotho |
| letsie i moshoeshoe of lesotho King of Lesotho (b. 1811) |
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| letsie ii lerotholi Lesotho chief (b. 1867) |
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letsie iii King of Lesotho, LS (b. 1963) |
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| walter tebogo letsie member of the National Assembly of South Africa |
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| tebogo letsie South African politician |
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Mr, Nneo, Emma, Hope, Maria, Mathe, Maite, Mampe, Maama, Mavis, Mohau, Moses, Muntu, Mbali, Mpiti, Sarah, Sinah, Simon, Sello, Sempe, Seiso, Solly, Nono, Napo, Nako, Toka, Ms, Sam, Dee, Neo, Mary, Mase, Mosa, Mpho, Soko, Anna, Steve, Keke, Pako, Pule, Rose, Ruth, Lebo, Lefa, Libe, Lolo, John, Joel, Paul, and Alice