Cognomen Knöpfle (Knöpfle 
) , across the world, is quite a rare surname. The family name Knöpfle is characteristic of Western Europe, particularly Germany, where it is quite a rare surname.
| VARIANT | COUNTRY |
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| Knöpfle | Germany, United States, Croatia |
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georg knöpfle German footballer and manager (1904-1987), DE (b. 1904) |
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| franz knöpfle German jurist, DE (b. 1926) |
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| robert knöpfle (b. 1931) |
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| christian knöpfle (b. 1967) |
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| karl tasso knöpfle researcher (ORCID 0000-0002-6155-8900) |
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| christian knöpfle Dr.-Ing. Technische Universität Darmstadt 2004 |
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| peter knöpfle |
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| felix knöpfle |
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| johanna knöpfle (b. 1984) |
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Jan, Klaus, Petra, Peter, David, Donat, Georg, Jakob, Josef, Julia, Jutta, Nadja, Elias, Erich, Ernst, Erwin, Heinz, Horst, Franz, Fritz, Felix, Willi, Kevin, Bernd, Achim, Anika, Tim, Sven, Anna, Anja, Karl, Paul, Pius, Ralf, Rolf, Rita, Xaver, Lisa, Joel, Hans, Otto, Maria, Marco, Michi, Simon, Alina, Alois, Anton, Luca, and Martin