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Surname Isom (Isom , Исом ) , in the entire world, is a common last name. The last name Isom is habitual in the United States, where it is quite a rare surname, Papua New Guinea, and Malaysia, where it is a rare surname. In absolute terms, it is commonest in the United States, Indonesia, and the United Kingdom. Very seldom, Isom is the forename as well as the last name.