Surname Desantis (Desantis 
, Десантіс 
, Десантис) , throughout the world, is a common last name. The cognomen Desantis is habitual in Italy, where it is quite a rare surname, the United States, and Canada. Much less frequently, Desantis is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Desantis | Italy, Canada, Argentina, United States, France |
| Десантіс | Ukraine |
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tullio desantis American artist and artist, US (b. 1948) |
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mark desantis American tech entrepreneur and consultant, US (b. 1959) |
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| tony desantis American entrepreneur and theater owner, US (b. 1914) |
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| dan desantis Player of American and Canadian football (1918-2004), US (b. 1918) |
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ron desantis 46th Governor of Florida, US (b. 1978) |
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casey desantis American television news host and First Lady of Florida, US (b. 1980) |
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derek desantis American musician, US (b. 1982) |
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jason desantis American ice hockey player, US (b. 1986) |
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| ann desantis American journalist, US (b. 1946) |
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| stanley desantis American actor (1953-2005), US (b. 1953) |
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| joe desantis American basketball player-coach, US (b. 1957) |
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| marko desantis American musician, US (b. 1972) |
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| mark desantis Canadian ice hockey defenceman and coach, CA (b. 1972) |
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| jaclyn desantis American actress, US (b. 1979) |
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| jenny desantis researcher |
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