Surname Παπαναστασίου (Papanastasiu 
, Papanastasiou 
, Παπαναστασίου ) , throughout the world, is quite a common last name. The last name Παπαναστασίου is characteristic of Cyprus, where it is quite a common surname, Greece, and Montenegro, where it is quite a rare surname. Measured by absolute frequency, it most frequently occurs in Greece, Cyprus, and the United States. Very seldom, Παπαναστασίου is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Papanastasiu | Bulgaria, Poland, Germany |
| Papanastasiou | Australia, Serbia, Greece, United States, Cyprus |
| Παπαναστασίου | Greece |
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αλέξανδρος παπαναστασίου Greek politician (1876-1936), GR (b. 1876) |
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κώστας παπαναστασίου Greek actor, singer, and writer, GR (b. 1937) |
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| νίκος παπαναστασίου Greek actor, GR (b. 1936) |
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| αναστάσιος παπαναστασίου Greek water polo player (born 1964), GR (b. 1964) |
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| γεωργία παπαναστασίου GR (b. 1955) |
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| παναγιώτης παπαναστασίου Greek politician, GR |
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| κωνσταντίνα παπαναστασίου Greek actress, GR |
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| θωμάς παπαναστασίου Greek actor, GR |
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| γεωργία παπαναστασίου Greek sportsperson, GR |
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| τάκης παπαναστασίου GR |
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| αργύρης παπαναστασίου CY |
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Ιωάννης, Νάνσυ, Κώστας, Νίκος, Μαρία, Αλέξανδρος, Πέτρος, and Παναγιώτης