Family name Witherspoon (Wether 
, Witherspoon 
) , throughout the world, is a common surname. The surname Witherspoon is habitual in the United States, where it is quite a rare surname, New Zealand, and Canada, where it is a rare surname. Not in comparison with a country's population, the name is most common in the United States, the United Kingdom, and Canada.
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| Wether | Venezuela, Brazil, United Kingdom, United States, Belgium |
| Witherspoon | Australia, Canada, New Zealand, United Kingdom, United States |
Spong, Weatherspoon, and Wotherspoon
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john witherspoon Scottish-American Presbyterian minister and Founding Father of the United States (1723-1794), US (b. 1723) |
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| helen witherspoon (1735-1785) (b. 1735) |
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| robert witherspoon American politician (1767-1837), US (b. 1767) |
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| james witherspoon American politician, US (b. 1784) |
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| isaac donnom witherspoon American lawyer (1803-1858), US (b. 1803) |
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| thomas sydenham witherspoon American Presbyterian minister (b. 1805) |
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samuel andrew witherspoon American politician, US (b. 1855) |
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| james hervey witherspoon, jr. Confederate Army officer and american politician, US (b. 1810) |
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herbert witherspoon American operatic bass, US (b. 1873) |
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cora witherspoon actress (1890-1957), US (b. 1890) |
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| george washington witherspoon Florida state legislator (1845–1892), US (b. 1845) |
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| t. d. witherspoon (b. 1836) |
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| john a. witherspoon American physician (1864-1929), US (b. 1864) |
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jimmy witherspoon American jump blues singer, US (b. 1920) |
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| frances m. witherspoon American writer and activist (1886-1973) (b. 1886) |
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