Surname Santiago-Reyes (Santiago-Reyes 
) , around the globe, is a very rare last name. The cognomen Santiago-Reyes is habitual in Northern America, particularly the United States, where it is an extremely rare surname. Parts of the name also exists independently as a last name Santiago, and a last name Reyes.
| VARIANT | COUNTRY |
|---|---|
| Santiago-Reyes | United States |