Surname Papaioannu (Papaioannu 
, Παπαϊωάννου 
, Папаиоанну 
) , throughout the world, is a rare last name. The family name Papaioannu is habitual in Greece, where it is a rare surname, North Macedonia, and Bulgaria. In absolute terms, it is commonest in Southern Europe, particularly Greece, Italy, and North Macedonia.
| VARIANT | COUNTRY |
|---|---|
| Papaioannu | Germany, Italy, Bulgaria, United States, North Macedonia |
| Παπαϊωάννου | Greece |
| Папаиоанну | Russia |
Παπαιωάννου, and Папаіоанну
| despina papaioannu |
|