Last name Osorio (Osorio 
, Osório 
, Осорио 
) , all around the world, is a widespread cognomen. The last name Osorio is characteristic of Latin America and the Caribbean, particularly Colombia, where it is a common surname, Guatemala, and El Salvador (explore the name in all countries). Measured by absolute frequency, it is the most numerous in Latin America and the Caribbean, particularly Colombia, Mexico, and Guatemala. Much less frequently, Osorio is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Osorio | Guatemala, Mexico, Colombia, Philippines, Peru |
| Osório | Portugal, Mexico, Colombia, Brazil, United States |
| Осорио | Russia |
| אוסוריו | Israel |
| gonzalo osorio (b. 1101) |
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| osorio gonzález (b. 1101) |
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| álvar núñez osorio ES (b. 1300) |
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inés de osorio (b. 1401) |
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| alvar pérez de osorio Spanish military personnel (1430-1471), ES (b. 1430) |
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| luis osorio Roman Catholic bishop, ES (b. 1435) |
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| constanza de castro y osorio ES (b. 1430) |
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| álvaro pérez osorio, iii marqués de astorga (b. 1450) |
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| pedro álvarez osorio ES (b. 1450) |
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| maría osorio y pimentel (1498-1539), ES (b. 1490) |
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| diego alvarez de osorio NI (b. 1485) |
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| isabel osorio Spanish courtier (b. 1522) |
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| antonio de osorio Spanish nobleman, soldier and politician, ES (b. 1545) |
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| lope de moscoso osorio (1555-1636) (b. 1555) |
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| juan torres de osorio 17th-century Spanish Catholic bishop, ES (b. 1562) |
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