Across the world, Mthulisi (Mthulisi 
) is a rare male given name. The first name Mthulisi is characteristic of Sub-Saharan Africa, particularly Botswana, where it is quite a rare masculine name, Zimbabwe, and South Africa, where it is a rare primarily male, but very seldom feminine name.
| VARIANT | COUNTRY |
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| Mthulisi | Zimbabwe, Botswana, United Kingdom, South Africa, United States |
| mthulisi khuphe researcher |
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| mthulisi maphosa Zimbabwean football midfielder, ZW (b. 1983) |
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| mthulisi maphosa Zimbabwean association football player, ZW (b. 1989) |
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Ca, Dladla, Gumede, Tshuma, Nyathi, Ndlovu, Hadebe, Matiwaza, Malinga, Mabutho, Maphosa, Msimang, Mhlanga, Mkhonza, Mthembu, Sithole, Sibanda, Khumalo, Dlamini, Ngwenya, Ndiweni, Ndebele, Kumalo, Bhebhe, Supedzo, Mkhize, Moyo, Cele, Duma, Dube, Zulu, Mpofu, Mnisi, Mlilo, Shoko, Khoza, Ndhlovu, Khupe, Nyoni, Nkosi, Nkomo, Nkala, Ncube, Floyd, Zimba, Maseko, Masuku, Mdluli, Gumbo, and Msimanga