Family name 大西 (Onishi 
, 大西 , Ониси 
) , in all the world, is quite a rare last name. The surname 大西 is habitual in Paraguay, where it is quite a rare surname, Bolivia, and Taiwan, where it is a rare surname. In absolute terms, it is commonest in Brazil, Japan, and the United States. Very seldom, 大西 is the forename as well as the last name.
| 大西源一 Japanese historian (1883-1962), JP (b. 1883) |
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| 大西京子 Japanese author (1924-1989), JP (b. 1924) |
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大西裕之 basketball player (1981-), JP (b. 1981) |
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| 大西みつぐ Japanese photographer, JP (b. 1952) |
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| 大西昌之 Japanese association football player, JP (b. 1977) |
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| 大西玲子 actor, JP (b. 1982) |
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| 大西めぐみ JP (b. 1976) |
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| 大西沙織 Japanese voice actress, JP (b. 1992) |
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| 大西真美 JP (b. 1986) |
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