Surname Σπύρου (Spirou 
, Spyrou , Σπύρου ) , around the globe, is quite a common cognomen. The family name Σπύρου is characteristic of Cyprus, where it is a common surname, Marshall Islands, where it is quite a common surname, and Greece. Not in comparison with a country's population, the name is most common in Greece, Cyprus, and the United Kingdom. Much less frequently, Σπύρου is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Spirou, Spyrou | Cyprus, United Kingdom, Greece, United States, Australia |
| Σπύρου | Greece |
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ιωάννης σπύρου GR (b. 1905) |
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σπύρος σπύρου Greek politician, GR |
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| παναγιώτης σπύρου Greek cardiac surgeon, GR (b. 1936) |
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| κρις σπύρου American politician, US (b. 1943) |
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| δημήτρης σπύρου Greek film director, GR (b. 1954) |
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| σπύρος σπύρου Cypriot judoka, CY (b. 1956) |
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| σπύρος σπύρου Cypriot athletics competitor, CY (b. 1958) |
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| σταύρος σπύρου Cypriot footballer, CY |
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| μαρίνα ευθυμιάτου σπύρου greek sound designer, GR |
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| βασίλης σπύρου Greek actor, GR |
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| φώτης σπύρου Greek actor, GR |
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| μπενέτος σπύρου GR |
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