Surname Παπαϊωάννου (Παπαϊωάννου 
, Papaioannu 
) , globally, is a rare cognomen. The surname Παπαϊωάννου is habitual in Greece, where it is a rare surname, North Macedonia, and Bulgaria. Measured by absolute frequency, it is the most numerous in Southern Europe, particularly Greece, Italy, and North Macedonia.
| VARIANT | COUNTRY |
|---|---|
| Παπαϊωάννου | Greece |
| Papaioannu | Germany, Italy, North Macedonia, United States, Bulgaria |
| λουκάς παπαϊωάννου Greek doctor, politician and university professor, GR (b. 1831) |
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νίκανδρος παπαϊωάννου BG (b. 1877) |
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| νικόλαος παπαϊωάννου Greek politician, GR (b. 1855) |
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γιάννης παπαϊωάννου Greek composer (1910-1989), GR (b. 1910) |
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| ιωάννης παπαϊωάννου Greek singer and actor, GR (b. 1869) |
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μιλτιάδης παπαϊωάννου Greek politician, GR (b. 1947) |
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| βούλα παπαϊωάννου Greek photographer, GR (b. 1898) |
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| κωνσταντίνος παπαϊωάννου Greek university professor, GR (b. 1899) |
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| ανδρέας παπαϊωάννου Greek gymnast, GR (b. 1900) |
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| γεώργιος παπαϊωάννου Greek physician and politician, GR (b. 1900) |
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| μαρίκα παπαϊωάννου Greek pianist and music teacher, GR (b. 1904) |
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| εζεκίας παπαϊωάννου Cypriot politician, CY (b. 1908) |
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| δημήτριος παπαϊωάννου Greek politician, GR (b. 1909) |
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| νικόλαος ι. παπαϊωάννου Greek lawyer and politician, GR (b. 1913) |
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| γιάννης παπαϊωάννου Greek musician (1913-1972), GR (b. 1913) |
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