Family name Yefrem (Ефрем 
, Єфрем , Yefrem 
) , globally, is a rare cognomen. The cognomen Yefrem is characteristic of Bulgaria, where it is quite a rare surname, Armenia, where it is a rare surname, and Ukraine. In absolute terms, it is the most numerous in Eastern Europe, particularly Bulgaria, Ukraine, and Russia. More prevalently, Yefrem is the forename as well as the last name.
Zats, Janashvili, Yerusalymsky, Patsukevych, Alterman, Immerman, Polussa, Bitkine, Hernandez, Shifrin, Lysker, Leykin, Anikin, Solyar, Touma, Pekar, Kozin, Melamed, and Yefremashvili