Surname Serena (Serena 
, سيرينا 
, セレナ 
, and others...) , in the entire world, is a common cognomen. The surname Serena is characteristic of Italy, where it is quite a rare surname, Spain, and Israel. Not in comparison with a country's population, it is the most numerous in Italy, Spain, and Mexico. More frequently, Serena is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Serena | Spain, Italy, United States, Democratic Republic of the Congo, China |
| سيرينا | Iraq, Jordan, Egypt, Syria, Algeria |
| セレナ | Japan |
| Серена | Russia, Ukraine, Kyrgyzstan |
| סרנה | Israel |
| agostino serena Swiss architect, CH (b. 1580) |
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| pedro de la serena Roman Catholic bishop (b. 1630) |
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| domenico serena Swiss engineer, CH (b. 1650) |
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carla serena Belgian author (1820-1884), BE (b. 1820) |
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| raffaele serena Roman Catholic bishop (b. 1776) |
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ottavio serena Italian politician (1837-1914), IT (b. 1837) |
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luigi serena Italian painter (1855-1911), IT (b. 1855) |
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gustavo serena Italian actor, IT (b. 1881) |
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clara serena (1890-1972) contralto (b. 1890) |
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adelchi serena Italian politician (1895-1970), IT (b. 1895) |
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| arthur serena Italian-Belgian financier and benefactor, BE (b. 1853) |
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| augusto serena Italian historian (1868-1946), IT (b. 1868) |
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bill serena American baseball player (1924-1996), US (b. 1924) |
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| sebastiano serena Italian priest, teacher and librarian (1882-1959), IT (b. 1882) |
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| carlo serena roman-catholic archbishop (1882-1972), IT (b. 1882) |
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Li, White, Young, Zhang, Martin, Miller, Garcia, Taylor, Thomas, Nguyen, Harris, Walker, Wilson, Wright, Jackson, Johnson, Martinez, Anderson, Robinson, Thompson, Esposito, Williams, Huang, Rodriguez, Jones, Lewis, Ng, Wu, Lee, Lin, Lim, Liu, Tan, Chan, Chen, King, Wang, Wong, Yang, Moore, Silva, Scott, Smith, Brown, Rossi, Russo, Davis, Lopez, and Hernandez