Cognomen Senecio (Senecio 
) , throughout the world, is a rare family name. The cognomen Senecio is characteristic of Philippines, where it is a rare surname, Mexico, where it is a very rare surname, and Venezuela. Also, Senecio is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Senecio | Mexico, Brazil, Peru, Argentina, Philippines |
| herennius senecio 1st century Roman Stoic, quaestor and writer (b. 50) |
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| quintus sosius senecio late 1st/early 2nd century Roman senator, consul and governor (b. 100) |
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| lucius alfenus senecio last governor of all Roman Britain prior to its division into multiple provinces (b. 101) |
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| publius orfidius senecio (b. 150) |
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| c. iulius senecio équite and imperial procurator of the severe period, VA |
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