Cognomen Santa Luisa (Santa Luisa 
) , worldwide, is a very rare family name. The surname Santa Luisa is characteristic of Latin America and the Caribbean, particularly Mexico, where it is a very rare surname, and Argentina, where it is an extremely rare surname. More prevalently, Santa Luisa is the forename as well as the last name.
| VARIANT | COUNTRY |
|---|---|
| Santa Luisa | Mexico, Argentina, Peru, Italy, Ecuador |