Cognomen Sampelayo (Sampelayo 
) , in the entire world, is a very rare surname. The last name Sampelayo is habitual in Spain, where it is a rare surname, Portugal, where it is a very rare surname, and Peru. Measured by absolute frequency, it is commonest in Spain, the United States, and Portugal. Also, Sampelayo is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Sampelayo | Argentina, Peru, United States, Portugal, Spain |
| maría moll sampelayo (b. 1873) |
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| primitivo hernández sampelayo ES (b. 1880) |
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| juan h. sampelayo Spanish journalist, ES (b. 1910) |
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| teresa hernández sampelayo researcher |
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| josé alcántara sampelayo ES |
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| juan sampelayo |
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| sara sampelayo |
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