Cognomen Mphephu (Mphephu 
) , globally, is quite a rare family name. The surname Mphephu is habitual in Sub-Saharan Africa, particularly South Africa, where it is quite a rare surname. Also, Mphephu is the forename as well as the last name.
| VARIANT | COUNTRY |
|---|---|
| Mphephu | South Africa, United States, United Kingdom |
| patrick mphephu South African politician (1924-1988), ZA (b. 1924) |
|