Family name Khomotso (Khomotso 
) , in all the world, is a rare surname. The surname Khomotso is characteristic of South Africa, where it is a rare surname, and the United States, where it is an extremely rare surname. Much more frequently, Khomotso is the forename as well as the last name.
Maake, Mashile, Mashego, Mohlala, Mokoena, Mokwena, Moabelo, Comfort, Ledwaba, Manamela, Malapane, Maluleke, Mahlangu, Masemola, Makofane, Mamabolo, Chiloane, Precious, Letsoalo, Thobejane, Mashabela, Mphahlele, Mashaba, Sekgobela, Malatji, Legodi, Motso, Khomo, Khoza, Phala, Langa, Nkosi, Matlou, Maleka, Malepe, Madiba, Mohale, Moloto, Modiba, Mogale, Aphane, Baloyi, Bopape, Kekana, Khomza, Kgatla, Phasha, Matlala, and Nkadimeng