Cognomen Khama (Khama 
, Хама 
, קאמה 
) , around the globe, is quite a common last name. The surname Khama is habitual in Sub-Saharan Africa, particularly Lesotho, where it is quite a common surname, Botswana, and Namibia, where it is quite a rare surname. Not in comparison with a country's population, it is commonest in Lesotho, India, and South Africa. More frequently, Khama is the forename as well as the last name.
| semane setlhoko khama mohumagadi of the BaNgwato in the Bechuanaland Protectorate (Botswana) (b. 1881) |
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ian khama seretse khama Motswana politician, BW (b. 1953) |
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| seretse khama First President of Botswana (1921–1980), BW (b. 1921) |
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| ruth williams khama First Lady of Botswana (1923-2002), BW (b. 1923) |
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