Cognomen Kassambe-Leyono (Kassambe-Leyono 
) , all around the world, is a rare family name. The last name Kassambe-Leyono is habitual in Sub-Saharan Africa, particularly the Democratic Republic of the Congo, where it is a rare surname. Parts of the name also exists independently as a last name Kassambe, and a last name Leyono.
| VARIANT | COUNTRY |
|---|---|
| Kassambe-Leyono | Democratic Republic of the Congo |