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Family name Isike (Isike ) , around the globe, is a rare last name. The surname Isike is characteristic of Sub-Saharan Africa, particularly Tanzania, where it is a rare surname, Nigeria, where it is a very rare surname, and South Africa, where it is an extremely rare surname. In absolute terms, it is commonest in Tanzania, Nigeria, and India. Likewise, Isike is the forename as well as the last name.