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Family name Isen (Isen , 伊森 , Исен ) , around the globe, is quite a rare last name. The surname Isen is characteristic of North Macedonia, where it is quite a common surname, Denmark, where it is quite a rare surname, and Hong Kong, where it is a rare surname. Measured by absolute frequency, it is the most numerous in North Macedonia, the United States, and Germany. Also, Isen is the forename as well as the last name.