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Family name Isay (Исай , Isay , 伊赛 ) , in all the world, is quite a rare last name. The family name Isay is habitual in Bulgaria, where it is quite a rare surname, Ethiopia, and Israel, where it is a rare surname. Measured by absolute frequency, this name is the most popular in Ethiopia, Bulgaria, and Mexico. Likewise, Isay is the forename as well as the last name.