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Family name Isai (Isai , Исай , イサイ ) , in the world, is a common last name. The family name Isai is habitual in Mexico, where it is quite a common surname, Honduras, where it is quite a rare surname, and Namibia. Measured by absolute frequency, the name is most common in Mexico, India, and Romania. Likewise, Isai is the forename as well as the last name.