Family name Isack (Isack 
) , worldwide, is a common cognomen. The surname Isack is characteristic of Sub-Saharan Africa, particularly Tanzania, where it is quite a common surname, Namibia, where it is quite a rare surname, and Somalia. In absolute terms, this name is the most popular in Sub-Saharan Africa, particularly Tanzania, Somalia, and Kenya. Likewise, Isack is the forename as well as the last name.
| VARIANT | COUNTRY |
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| Isack | Tanzania, South Africa, Kenya, Somalia, Brazil |
| alfons isack holocaust victim, b. 1912-05-27, DE (b. 1912) |
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| marianne isack holocaust victim, b. 1922-04-04, DE (b. 1922) |
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| hussein adan isack Kenyan scientist (b. 1957) |
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| rajasekaran isack Indian entomologist |
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