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Surname Brein (Brain , Brein , Брейн ) , in the world, is a common last name. The cognomen Brein is habitual in Isle of Man, where it is quite a common surname, Ghana, where it is quite a rare surname, and the United Kingdom. In absolute terms, it is the most numerous in the United Kingdom, Ghana, and the United States. Also, Brein is the forename as well as the last name.