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Cognomen Brain (Brain , Brein , Брайн ) , around the world, is a common surname. The surname Brain is characteristic of Isle of Man, where it is quite a common surname, Ghana, where it is quite a rare surname, and the United Kingdom. Measured by absolute frequency, this name is the most popular in the United Kingdom, Ghana, and the United States. Likewise, Brain is the forename as well as the last name.